tmem leverantör notering - även för - BuyersGuideChem
PLOS ONE: Hämning av kalciumaktiverade kloridkanal ANO1
T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Welcome to PubChem! … T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.
Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Cited in 8 25 Jun 2019 T16Ainh-A01 is an inhibitor of TMEM16A. Guinea pigs with a male to female ratio of 1:1 and a body weight of 150–450 g were housed in a low- 21 Oct 2019 C, qPCR analysis of TP63 expression in EPC2-ALI cells stimulated for 48 hours with T16Ainh-A01 (10 mmol/L) or dimethyl sulfoxide (DMSO) as a 23 Feb 2018 Three of these – MONNA, Ani9, and T16ainh-A01 – were. 176 previously reported to target human and/or mouse TMEM16A [44-46], whereas 13 May 2014 inhibitor T16Ainh-A01.
Show Size & Price TMEM16A Inhibitor, T16Ainh-A01. REACH- registreringsnummer: Det finns inget registreringsnummer för denna substans eftersom substans.
613551 Produktnamn: TMEM16A Inhibitor, T16Ainh-A01
在兔肺动脉心肌细胞中，T16Ainh-A01（1-30μM）抑制由500nM游离Ca2+激活的全细胞电流。 References: [1] Alison J Davis, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01. Br J Pharmacol.
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It appears that your browser has JavaScript disabled. An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC 50 = 1.1 µM).
Chemsrc provides T16Ainh-A01(CAS#:552309-42-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of T16Ainh-A01 are included as well.
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Formel. T16Ainh - A01. 552309-42-9.
T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).
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tmem leverantör notering - även för - BuyersGuideChem
Cited in 8 publications. T16Ainh-A01 relax rodent resistance arteries in a concentration dependent way, an equivalent vasorelaxation occurs in rodent arteries when the transmembrane chloride gradient is abolished with an impermeant anion), 23 this reduces the reliability of T16Ainh-A01's dependence on TMEM16A. T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM.
tmem leverantör notering - även för - BuyersGuideChem
Buy Calcium Channel inhibitor T16Ainh - A01 from AbMole BioScience. Vulcanchem offers qualified products for CAS No. 552309-42-9(T16Ainh-A01), please inquire us for more detail. 2015-07-01 · Intrathecal administration of selective CaCCs inhibitors (T16Ainh-A01 and CaCCinh-A01) also dose-dependently diminished tactile allodynia and thermal hyperalgesia. Anoctamin-1 and bestrophin-1 mRNA and protein were expressed in the dorsal spinal cord and DRG of naïve, sham and neuropathic rats.
References: MONNA, T16Ainh -A01, and Ani9 attenuated 5-HT/U46619-induced contractions. MONNA and T16Ainh -A01 also increased coronary flow in Langendorff perfused rat heart preparations. TMEM16A mRNA was increased in coronary artery smooth muscle cells from SHRs, and U46619 and 5-HT were more potent in arteries from SHRs than in those from normal Wistar rats.