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Open a version of this ORCID 2019-01 | journal-article. DOI: 10.1016/j.bbr.2018.08.034. May 15, 2002 Continued progress with lead product BBR 2778 for Non-Hodgkin's Lymphoma ( NHL): - Phase III study in indolent NHL approved by the Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Nov 16, 2007 Abstract. The CHOP-R regimen is the standard regimen for first-line therapy of patients with DLBCL.

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Unlike other intelligence solutions, BCIQ exclusively supports the unique needs of the biopharma industry and Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

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Download Citation | On Jan 1, 2000, E.B. Skibo published BBR-2778 Novuspharma SpA | Find, read and cite all the research you need on ResearchGate Pixantrone (BBR 2778) is an experimental antineoplastic drug.;Target: Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines [1]. BBR 28 1 Boverkets föreskrifter om ändring i Boverkets byggregler (2011:6) - föreskrifter och allmänna råd; Utkom från trycket den 19 september 2019 beslutade den 17 september 2019. Boverket föreskriver med stöd av 10 kap. 3 och 4 §§ plan- och byggförordningen (2011:338) i fråga om Boverkets byggregler (2011:6) – Pixantrone (BBR 2778) ~ Recruitment for the phase III study in relapsed indolent NHL is underway with 100 centres being opened worldwide.

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Cytarabine. BBR 2778. Pixantrone. BSA. Dec 12, 2018 (2003) Phase-II study of the new aza- anthracenedione, BBR 2778, in patients with relapsed aggressive non-Hodgkin's lymphomas. Dec 19, 2018 Pixantrone (Pixuvri, BBR 2778) is a cytotoxic aza‐anthracenedione that directly alkylates DNA, forming stable DNA adducts and cross‐strand Oct 21, 2020 https://orcid.org/0000-0003-2778-0943.

Pixantrone (BBR 2778) is a novel Criscuolo will oversee development of Novuspharma's clinical programs, including preregistration studies with BBR 2778, the company's lead product for non- May 5, 2007 of compounds, BBR 2778 (6,9-bis[(2-aminoethyl)amino] benzo[g]isoquinoline-5, 10-dione dimaleate) emerged as the most promising drug May 5, 2007 BBR 2778 (subsequently named Pixantrone™; Figure 1 ) demonstrated superior anti-leukemic activity in mice over a wide, well-tolerated range Jan 19, 2010 7, Pixantrone (BBR 2778), Cell Therapeutics, Filed, 48, 449. 8, Xiaflex, Auxilium Pharmaceuticals + Pfizer, Filed, 53, 386. 9, Movectro, Merck 化学名, 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione.
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1: pixantrone [Supplementary Concept] an immunosuppressant; structure given in first source Date introduced: May 2, 1994 Registry Number: F5SXN2KNMR Heading Mapped to: Isoquinolines Entry Terms: 5,8-bis(2-aminoethylamino)-2-azaanthracene-9,10-dione 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione 5,8-bis((2-aminoethyl)amino)-2-aza-anthracene-9,10-dione 6,9-AEA-BIQDO BBR 2778 BBR2778 BBR 2778, a novel anthracenedione, induces DNA intercalation and inhibition of the topoisomerase-II enzyme. In this study BBR 2778 was given as a 1 h intravenous infusion weekly for 3 weeks (w) every 4 w. Synonym: 2-Azaanthracene-9,10-dione dimaleate, 6,9-Bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate, BBR 2778, BBR-2778, BBR2778, Pixantrone maleate Empirical Formula (Hill Notation): C 17 H 19 N 5 O 2 · C 8 H 8 O 8 Pixantrone Dimaleate is the dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Keywords:BBR-2778, cardiotoxicity, non-Hodgkin, lymphoma, pixantrone, Pixuvri ®. Abstract:This review will trace the steps in the development of pixantrone dimaleate (initial code BBR 2778, Pixruvi ®), an anthracenedione chemotype, as a chemotherapeutic agent. Rank Web of Science journal category Relevance score (tfidf) Class's shr.

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Although against in vivo models BBR 2778 was less potent than mitoxantrone and doxorubicin, its antitumor activity was equal or superior (in certain tumor models) to that of the above standard compounds. BBR 2778 is a novel aza-anthracenedione that has activity in experimental tumors and shows reduced potential for cardiotoxicity in animal models. This cytotoxic agent has structural similarities with mitoxantrone as well as general similarities with anthracyclines (such as the tricyclic central quinoid chromophore). Phase-II study of the new aza-anthracenedione, BBR 2778, in patients with relapsed aggressive non-Hodgkin's lymphomas These results indicate that 85 mg/m2 BBR 2778 in a q1w x 3 schedule is active in elderly and pretreated patients with relapsed aggressive NHL and was generally well tolerated. A novel aza-anthracenedione, pixantrone (BBR 2778), was developed to reduce treatment-related cardiotoxicity while retaining efficacy. This study evaluates the cumulative cardiotoxic potential of pixantrone compared with equiactive doses of doxorubicin and mitoxantrone in both doxorubicin-pretreated and doxorubicin-naïve mice.